The control of microbial burden on surfaces such as in GMP production areas, R&D animal labs and hospitals is a daily challenge. Many rooms have high ceilings and are equipped with complex equipment, furniture, computers, etc. In practice it turns out that disinfection by wiping is a difficult task under these circumstances. Major drawbacks found consist of the following:
- difficult to access surfaces and areas: ceiling, areas behind and under furniture and fixtures.
- contact time and pressure applied are highly dependent of personnel.
- uniformity of application on all surfaces and reproducibility difficult to obtain and to prove.
- laborious and time-consuming.
- its validation is very intricate.
Alternatively, airborne disinfection by means of nebulisation techniques allows overcoming many critical aspects of wiping in both procedure and validation. Moreover, the use of hydrogen peroxide (H2O2) with moderate concentration resolves remaining reservations as to toxicity, corrosion, and persistence. H2O2 decomposes into water (H2O) and oxygen (O2) over time and does not leave residues.